Annual Banned-Substance Review 17th Edition - Analytical Approaches in Human Sports Drug Testing 2023/2024 / Mario Thevis, Tiia Kuuranne, Hans Geyer
- Drug Testing and Analysis (28 December 2024), p. 1-26
- PMID: 39731401
- DOI: 10.1002/dta.3835
Contents:
- Introduction
- Non-Approved Substances
- Anabolic Agent
- Anabolic-androgenic steroids
- Initial testing procedures and Studies on Metabolism
- Steroid profiling in urine and blood
- Other Anabolic Agents
- Peptide Hormones, Growth Factors, Related Substances, and Mimetics
- EPO-receptor agonists (ERAs) and hypoxia-inducible
factor (HIF) activating agents - Peptide hormones and their releasing factors
- EPO-receptor agonists (ERAs) and hypoxia-inducible
-
Β2-Agonists, Hormone, And Metabolic Modulators, and diuretics
- β2-Agonists
- Hormone and metabolic modulators
- Diuretics
- Stimulants And Glucocorticoids
- Stimulants
- Glucocorticoids
- Manipulation Of Blood And Blood Components
- Chemical and Physical Manipulation
- Gene and Cell doping
- Conclusion And Perspectives
Abstract
The 17th edition of the annual banned-substance review on analytical approaches in human sports drug testing is dedicated to literature published between October 2023 and September 2024. As in previous years, focus is put particularly on new or enhanced analytical options in human doping controls as well as investigations into the metabolism and elimination of compounds of interest, which represent central (while not exclusive) cornerstones of the global anti-doping mission. New information published within the past 12 months on established doping agents as well as new potentially relevant substances are reviewed and discussed in the context of the World Anti-Doping Agency's 2024 Prohibited List. Thereby, analytical challenges, especially with regard to the continuously growing number of target compounds and potentially relevant drug classes as well as the exigency (and consequences) of utmost analytical retrospectivity, are thematized and contextualized. Investigations especially into anabolic agents, peptide hormones, and strategies for the detection of gene doping were identified as core areas of anti-doping research in the reviewed period.
