Annual banned-substance review : analytical approaches in human sports drug testing / Mario Thevis, Tiia Kuuranne, Hans Geyer. - (Drug testing and analysis 10 (2018) 1 (January); p. 9-27)
- PMID: 29149502
- DOI: 10.1002/dta.2336
Contents:
- Introduction
- Non-Approved Substances
- Anabolic Agents
- Anabolic-androgenic steroids
- Initial testing procedures – metabolism studies and new target analytes
- Steroid profiling
- Confirmatory testing procedures - isotope ratio mass spectrometry (IRMS)
- Alternative test methods and approaches
- Other anabolic agents
- Peptide Hormones, Growth Factors, Related Substances, and mimetics
- Erythropoietin-receptor agonists
- Hypoxia-inducible factor stabilizers and activators
- Growth hormone and its releasing factors
- Insulin‐like growth factor‐1 (IGF‐1), chorionic gonadotrophin (hCG), and corticotrophin releasing factors
- β2‐Agonists
- Hormone and Metabolic Modulators
- Diuretics and other Masking Agents
- Stimulants, Narcotics, Cannaboinoids, and Glucocorticoids
- Manipulation of Blood and Blood Components
- Gene Doping
- Conclusion
Abstract
Several high-profile revelations concerning anti-doping rule violations over the past 12 months have outlined the importance of tackling prevailing challenges and reducing the limitations of the current anti-doping system. At this time, the necessity to enhance, expand, and improve analytical test methods in response to the substances outlined in the World Anti-Doping Agency's (WADA) Prohibited List represents an increasingly crucial task for modern sports drug-testing programs. The ability to improve analytical testing methods often relies on the expedient application of novel information regarding superior target analytes for sports drug-testing assays, drug elimination profiles, alternative test matrices, together with recent advances in instrumental developments. This annual banned-substance review evaluates literature published between October 2016 and September 2017 offering an in-depth evaluation of developments in these arenas and their potential application to substances reported in WADA's 2017 Prohibited List.
