Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion

Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion / Jacob Bejder, Andreas Breenfeldt Andersen, Sara Amalie Solheim, Mikkel Gybel-Brask, Niels H. Secher, Pär I. Johansson, Nikolai Baastrup Nordsborg. - (Medicine and science in sports and exercise (2018) 6 november).
- PMID: 30407276.
- DOI: 10.1249/MSS.0000000000001837


PURPOSE:
This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBCs) from a standard 450 ml phlebotomy would increase mean power in a cycling time trial. Additionally, the study investigated whether further ABT of RBCs obtained from another 450 ml phlebotomy would increase repeated cycling sprint ability.

METHODS:
In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450 ml blood bags each (BT-trial) or were sham phlebotomized (PLA-trial). Four weeks later, a 650 kcal time trial (n=7) was performed three days before and 2 h after receiving either ~50% (135 ml) of the RBCs or a sham transfusion. On the following day, transfusion of RBCs (235 ml) from the second donation or sham transfusion was completed. A 4×30 s all-out cycling sprint interspersed by 4 min of recovery was performed six days before and three days after the second ABT (n=9).

RESULTS:
The mean power was increased in time trials from before to after transfusion (P<0.05) in BT (213±35 vs. 223±38 W; mean±SD) but not in PLA (223±42 vs. 224±46 W). In contrast, the mean power output across the four 30 s sprint bouts remained similar in BT (639±35 vs. 644±26 W) and PLA (638±43 vs. 639±25 W).

CONCLUSION:
ABT of only ~135 ml of RBCs is sufficient to increase mean power in a 650 kcal cycling time trial by ~5% in highly trained men. In contrast, a combined high-volume transfusion of ~135 and ~235 ml of RBCs does not alter 4×30 s all-out cycling performance interspersed with 4 min of recovery.

Parameters

Science
Research / Study
Date
6 November 2018
People
Andersen, Andreas Breenfeldt
Bejder, Jacob
Gybel-Brask, Mikkel
Johansson, Pär I.
Nordsborg, Nikolai Baastrup
Secher, Niels H.
Solheim, Sara Amalie
Country
Denmark
Language
English
ADRV
Use / attempted use
Other organisations
Københavns Universitet - University of Copenhagen (UCPH)
Københavns Universitetshospital - Copenhagen University Hospital
Doping classes
M1. Manipulation Of Blood And Blood Components
Medical terms
Blood doping
Intravenous infusions
Document category
Abstract
Date generated
15 January 2019
Date of last modification
19 March 2019
Category
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period
Origin